The organisation says the dogs "need some special TLC before going to their new homes"
The Dublin Society for Prevention of Cruelty to Animals (DSPCA) is appealing for people to foster puppies for a few weeks.
The organisation says it has taken 19 puppies into its care this week, with many said to have been dumped in a "very poor condition".
The DSPCA says it will provide all the food and vet treatment needed if anyone is able to temporarily take the young dogs in for 3-4 weeks.
DSPCA CEO Brian Gillen explained: "We are looking for Fosterers who would be willing to help us care for these young dogs for a few weeks.
"Many of the puppies are suffering from skin conditions, are under weight and need some special TLC before going to their new homes."
The organisation is also offering to rehome any unwanted pups on a 'first come first served' basis, and will also neuter the puppies' mother free of charges.
"We continue to ask the public to neuter their animals and help to stop overpopulation of unwanted pets," the organisation added.
Anyone who can help is being asked to email firstname.lastname@example.org