There's also the Merseyside derby where Everton haven't won at Anfield since 1999
As we enter the business end of the Premier League season there's some huge fixtures this weekend which could well decide who gets those coveted Champions League places.
The stand out fixture this weekend sees Manchester City head to Arsenal with both managers under pressure after early high profile exits from the Champions League coupled with the failure to challenge for the league title.
The teams are also set to face off in the FA Cup semi-final later this month.
Arsenal go into the match after back-to-back 3-1 defeats to Liverpool and West Brom respectively and are six points adrift of the top four although they have two games in hand.
City have drawn their last two matches against Stoke and Liverpool and could do with a win before heading to Chelsea on Wednesday.
Swansea welcome Middlesbrough in a classic relegation six pointer at the other end of the table. The Welsh side are three points clear of Hull in 18th with their visitors a further two points back but they have a game in hand.
Middlesbrough haven't won in their last ten matches and go into the game on the back of three successive defeats while Swansea suffered reverses against Bournemouth and Hull recently.
Back then an early Kevin Campbell goal was enough for the win which included three players being shown red cards.
Everton haven't beaten their local rivals anywhere since a 2-0 win in October 2010 at Goodison Park. The blue half of Liverpool are also reeling form the news that both Seamus Coleman and Ramiro Funes Mori will miss the rest of the season through injury.
RK: "In one week we've lost three players from our starting XI. We still have a strong team for tomorrow." https://t.co/arMCQEN5YN— Everton (@Everton) March 31, 2017
Everton arrive at Anfield only six points adrift of their rivals and a win could draw them into an unlikely chase for a Champions League place.
Liverpool have played a game more than the three teams ahead of them and will need all three points to fend off the challenge of Man United and Arsenal directly behind them.