Egypt and Mali could not find the net
Ghana are the leaders after the first round of matches in Group D at the Africa Cup of Nations.
A penalty from West Ham's Andre Ayew gave the four time champions and 2015 runners up a 1-0 victory over Uganda, who have qualified for the first time since they finished second in 1978.
He converted on 32 minutes after Ghana captain Asamoah Gyan was fouled.
The victory puts them on three points, two clear of their nearest rivals with two rounds of group action still to play.
In the second game in Group D Arsenal midfielder Mohamed Elneny played in Egypt's goalless draw with Mali.
While no goals were forthcoming, from an Egypt point of view that was down to veteran goalkeeper Essam El-Hadary.
At the age of 44, he set a record for the oldest player to feature at an Africa Cup of Nations, celebrating with a clean sheet.
Tuesday's action mirrored the goals rate of Monday's Group C action when there was a goalless draw between Ivory Coast and Togo, and a narrow 1-0 victory for DR Congo over Morocco.
Only three teams have managed to score two goals in a match; Senegal in their 2-0 victory over Tunisia; and the 2-2 draw between Algeria and Zimbabwe.
Both of those games were in Group B.