Man United and Liverpool visit Everton an Bournemouth respectively
This Saturday's Premier League action is beginning with a huge clash at the top of the table between two clubs that have enjoyed success in the wake of the financial boost provided by their respective owners this Millennium.
But it's also an intriguing tactical clash between two of the game's great managers, Pep Guardiola and Antonio Conte.
But it also features some individuals in good form.
Manchester City's Sergio Aguero and Chelsea's Diego Costa have equal goals records this season in the Premier League.
Both former Atletico Madrid strikers have 10 goals each for 2016-17 so far, heading into Saturday's 12.30pm kick off but as we know they are very different players in terms of style and physical build.
Although Costa is the taller man, it's Aguero who has the only headed goal between them this season.
Both predominantly are also finding the net with their right feet at almost the same rate.
Starting with Sunday's match at Bournemouth, the Liverpool attacking midfielder is out for the next five weeks, which is a blow for the Reds as they look to maintain their Premier League momentum through the busy winter period.
He has become a key man since Jurgen Klopp's arrival as manager in mid-October 2015, although he has had his absences in that time.
When it comes to Klopp-era Premier League games that Coutinho has fully missed, Liverpool have won five times, drawn three and lost four.
Three of those defeats were away, coming against Manchester United, Newcastle and Leicester.
However, without Coutinho, they did overcome Bournemouth 2-1 away in April.
Manchester United make a trip to an Everton side that are just one point below them in the clutch of teams outside the Top 5.
It's also a fixture with sentimental value for Wayne Rooney as an Evertonian prior to his move to Man United all those years ago.
In comparison to his record against other Premier League sides during his career, his matches against Everton have provided relatively modest returns. Relatively is the key word here.
That being said, five goals and two assists read well, although the downside is four yellow cards.