Zane Kirchner takes his place against Edinburgh
The knee injury suffered by Rob Kearney is not as bad as first feared but the full-back is set to miss Leinster's upcoming Pro 12 games.
As a result, Zane Kirschner steps in at full-back for tomorrow's trip to Edinburgh due to the Irish international's absence.
Jamie Heaslip returns at No 8, with Devin Toner coming into the second row.
And completing a much-changed pack, Jack McGrath and Sean Cronin return to the front row.
Jamison Gibson-Park will make a first start for the province at scrum-half.
Meanwhile Isa Nacewa makes his first start, and will earn his 150th cap for the province.