Sean Reidy and Tiernan O'Halloran could both make their debuts from the bench
Quinn Roux will make his debut for Ireland this weekend, in the second test against South Africa.
There are five personnel changes to the side that started the first Test and a further five new faces among the replacements.
Rory Best captains the side and is joined in the front row by Jack McGrath and Tadhg Furlong. Devin Toner and Connacht's Roux combine in the second row with Iain Henderson switching to the blindside flank to join Rhys Ruddock at openside and Jamie Heaslip at No.8 in the backrow.
Conor Murray and Paddy Jackson are retained at half-back while Stuart Olding joins Robbie Henshaw in midfield. Craig Gilroy is introduced to the back three alongside Andrew Trimble and Jared Payne at fullback.
The replacements named are Richardt Strauss, Dave Kilcoyne, Finlay Bealham, Donnacha Ryan, Sean Reidy, Kieran Marmion, Ian Madigan and Tiernan O'Halloran.
Both Reidy and O'Halloran will make their debuts if they feature from the bench.
Ireland team and replacements to face South Africa
(15-9): Jared Payne, Andrew Trimble, Robbie Henshaw, Stuart Olding, Craig Gilroy, Paddy Jackson, Conor Murray.
(1-8): Jack McGrath, Rory Best (capt), Tadhg Furlong, Devin Toner, Quinn Roux, Iain Henderson, Rhys Ruddock, Jamie Heaslip.
Replacements (16-23): Richardt Strauss, David Kilcoyne, Finlay Bealham, Donnacha Ryan, Sean Reidy, Kieran Marmion, Ian Madigan, Tiernan O'Halloran.