The BBC's Tim Vickery spoke to Off the Ball event of the tournament
It is less than a year since Chile became South American champions, beating Argentina in the final in Santiago.
Despite the tournament only taking place last July, the best teams for South America will join the best of offer from North and Central America in a one-off Copa America Centenario. 16 teams will take part in the tournament in the United States.
The tournament is taking place to mark the centenary of the original Copa America in 1916. An idea to create the one-off event was only spoken about publicly for the first time in 2012.
All ten South American teams are taking part in the event, including champions Chile, along with Argentina and Brazil. They will be joined by six teams including the United States, Mexico and Costa Rica.
The BBC's Tim Vickery spoke to Off the Ball about the event and he thinks it may prove to be a logistical nightmare. "Some (teams) are travelling much more than others. Uruguay, their itinerary seems to be drawn up by a four-year-old with a felt-tip pen. They are criss-crossing the country with every game."
All the countries are bringing different standards of squads to the event. Brazil's Neymar is being rested until the Olympics, while Argentina and Uruguay are bringing his Barcelona team mates Lionel Messi and Luis Suarez to the event.
Vickery "will be interested to see how the CONCACAF sides do". He thinks teams like the United States and Mexico "will be more motivated than the South American teams" in the tournament.
Argentina will go into the tournament as favourites Vickery believes, but their defence will be crucial to have any hope of winning their first major international title since the 1993 Copa America. "Will they balance (their attack) with an efficient defence? That's one of the most fascinating questions of the competition."
The tournament begins in the early hours of Saturday morning with the United States play Colombia in California. The final takes place on June 26th in New York.