Pat Lam has made nine changes to the team that lost to Treviso last week
Bundee Aki and Matt Healy both return to the starting lineup for the top-of-the-table clash between Connacht and Glasgow Warriors on Saturday.
Tiernan O'Halloran and Kieran Marmion will also mark a 100th appearance each when they run out at the Sportsground. Aki, Healy and Marmion are three of nine personnel changes made by head coach Pat Lam for the sold out clash that will decide a home playoff spot.
Robbie Henshaw and AJ MacGinty also return to the team after starting on the bench last week against Treviso in Italy.
The league's highest capped player John Muldoon returns to captain the side at Number 8 behind a second row partnership of Ultan Dillane and Aly Muldowney. Finlay Bealham, the only player to have featured in all 28 games so far this season, is named to start at tighthead prop.
Commenting on the upcoming game, head coach Pat Lam said: "Going into play off rugby, we couldn't ask for a better challenge than playing the defending champions who are on fire at the moment. Glasgow are undefeated since February and they have threats all over the park."
"While we have our place in the play offs secure, we all know what it would mean to the club and the province if we can bring a semi-final to the Sportsground for the first time.
Connacht team and replacements to face Glasgow Warriors:
(15-9): Tiernan O'Halloran, Niyi Adeolokun, Robbie Henshaw, Bundee Aki, Matt Healy, AJ MacGinty, Kieran Marmion.
(1-8): Ronan Loughney, Tom McCartney, Finlay Bealham, Ultan Dillane, Aly Muldowney, Sean O'Brien, Jake Heenan, John Muldoon (capt).
Replacements (16-23): Dave Heffernan, JP Cooney, Rodney Ah You, Quinn Roux, Eoin McKeon, John Cooney, Shane O'Leary, Peter Robb.