We look back at some of the unforgettable clashes between the sides
With the age-old rivals set to showdown once again, and plenty at stake for both sides, we have decided to take a look back at some of the most memorable clashes between the sides in recent years.
2006 was a historic year for Munster as they tasted Heineken Cup success for the very first time following years of heartbreak in preceeding campaigns.
The Men in Red's famous victory over Biarritz will always be fondly remembered, and despite a stunning victory in the pool stages over Sale, it was their dismantling of Leinster in the quarter-final that was arguably their most impressive performance.
The Eastern province were in high spirits following a remarkable 41-35 victory of their own against Toulouse in the quarter-finals, but they failed to replicate that form and were completely outclassed in front of a packed Lansdowne Road, with Denis Leamy, Ronan O'Gara and Trevor Halstead touching down for Munster.
Following on from the 2006 humbling, Leinster were on the hunt for revenge in a historic Heineken Cup semi-final held at Croke Park with over 80,000 people in attendance.
However, history would not repeat itself as a Rocky Elsom inspired Leinster hit their stride early on while Johnny Sexton announced himself on the European stage as he deputised for Felipe Contepomi.
Tries from Gordon D'Arcy and Luke Fitzgerald rocked the reigning champions before Brian O'Driscoll's late intercept try sealed the inevitable.
A comprehensive victory at the RDS left no doubt about who the dominant Irish province were as Leinster tore Munster apart.
Johnny Sexton firmly established himself as the prime candidate for outhalf in the post-Contempomi era as he excelled in the 10 jersey while Shane Horgan, Brian O’Driscoll and Gordon D’Arcy all dotted down.
The game may best be remembered for an uncharacteristic moment from Munster stalwart John Hayes, who saw red for an ugly stamp on a young Cian Healy, summing up his side's frustrations.
Having won their third Heineken Cup just one week earlier, Leinster succumbed to a powerful Munster performance in the grand final of the Magners League.
With this victory, Munster ended their big game hoodoo over their biggest rivals at Thomond Park with 26,000 people in attendance.
Speedsters Doug Howlett and Keith Earls touched down for the home side who were on song to deny Leinster a European and domestic double, stemming the flow of their rivals' dominance and winning some well-deserved and much-needed silverware.