Both sides beat their opponents home and away
Real Madrid and Wolfsburg are the first clubs through to the Champions League quarter-finals.
After defeating Roma 2-0 away in the first leg, they completed the task tonight at the Santiago Bernabeu.
Roma had numerous chances on the night but it was Real Madrid who took their as Cristiano Ronaldo slotted Zinedine Zidane's side in front after converting a Lucas Vazquez cross.
James Rodriguez made it 2-0 on the night and 4-0 on aggregate when he finished from an angle.
Roma's Mohamed Salah reacts after missing a chance to score during the Champions League Round of 16, second leg, soccer match between Real Madrid and Roma at the Bernabeu stadium in Madrid, Spain, Tuesday, March 8, 2016. (AP Photo/Francisco Seco)
Meanwhile, Wolfsburg beat Gent 1-0 tonight thanks to a goal from former Chelsea forward Andre Schurrle late in the first half.
The German side were already 3-2 up from the first leg before Schurrle turned in Julian Draxler's pass with 15 minutes to go.