Itoje is one of only two changes to the team that beat Italy
Maro Itoje will make his first start for England after being named in the side to face Ireland at Twickenham on Saturday.
Head Coach Eddie Jones has made two changes to the team that won in Rome with Itoje replacing Courtney Lawes while prop Joe Marler is preferred to Mako Vunipola.
Lawes drops to the bench having coming into the squad for injured Wasps forward Joe Launchbury.
Wasps centre Elliot Daly is also among the replacements and is in line for his debut with Jones reverting back to five forwards and three backs on the bench after only naming two backs for the Italian game split on the bench.
The game against Ireland is Jones' first home game as head coach having already earned wins in Edinburgh and Rome. “Playing our first game at Twickenham after two away fixtures will be huge for us," Jones said. "We’re determined to put in a strong performance against a clever Irish side who are the benchmark of European rugby.”