The Ireland centre has not played since November
Pat Lam has made six changes from his Connacht side that lost last week in France to face Enisei-STM in the final pool game of the European Challenge Cup at the Sportsground on Saturday.
All four Connacht players named in the Ireland 6 Nations squad this week are included. Nathan White returns to join Ultan Dillane in the pack while Robbie Henshaw and Kieran Marmion return from injury to take their place in an otherwise unchanged backline.
Henshaw returns to the team after fracturing his hand in November against Munster. He has only made two appearances for Connacht this season
There is a new front row with the introduction of local players Denis Buckley and Dave Heffernan alongsideWhite while Eoghan Masterson, named at Number 8, allows captain John Muldoon return to blindside flanker.
Commenting on the team selection and the upcoming game, head coach Pat Lam said: "We know we will need a clinical and focused performance tomorrow that ensures we take our chances and scores. Enisei will be coming here with confidence following their defeats of both Brive and Newcastle in our pool. They are a big, physical side and can do some damage if they are given a chance. But it's up to us to take control of this game from the start.
Connacht team and replacements to face Enisei-STM
(15-9): Tiernan O'Halloran, Danie Poolman, Robbie Henshaw, Bundee Aki, Matt Healy, AJ MacGinty, Kieran Marmion.
(1-9): Denis Buckley, Dave Heffernan, Nathan White, Ultan Dillane, Aly Muldowney, John Muldoon (capt), James Connolly, Eoghan Masterson.
Replacements (16-23): Tom McCartney, Finlay Bealham, Rodney Ah You, George Naoupu, Sean O'Brien, Caolin Blade, Jack Carty, Rory Parata.