Mutant superbug in the US heralds start of the post-antibiotic era

Bacteria discovered in 49-year-old's urinary tract infection contains the mcr-1 gene - resistant even to colistin, the antibiotic of last resort

Health officials in the United States have reported the first case there of a patient with an infection resistant to all known antibiotics - raising fears that routine infections could be lethal.

"We risk being in a post-antibiotic world," said Thomas Frieden, director of the US Centers for Disease Control and Prevention.

He was referring to the urinary tract infection of a 49-year-old Pennsylvania woman who had not travelled in the previous five months.

Speaking at a National Press Club lunch in Washington DC, Mr Frieden, said the infection was not controlled even by colistin, an antibiotic that is reserved for use against "nightmare bacteria".

The infection was reported yesterday in a study appearing in Antimicrobial Agents and Chemotherapy, a publication of the American Society for Microbiology.

It said the superbug itself had first been infected with a tiny piece of DNA called a plasmid, which passed along a gene called mcr-1 that confers resistance to colistin.

"[This] heralds the emergence of truly pan-drug resistant bacteria," said the study, which was conducted by the Walter Reed National Military Medical Center.

"To the best of our knowledge, this is the first report of mcr-1 in the USA."

The patient visited a clinic on April 26 complaining of symptoms of a urinary tract infection, according to the study. Her current condition has not been released.




The study also recommended continued surveillance to determine the true frequency of the gene in the United States.

"It is dangerous and we would assume it can be spread quickly, even in a hospital environment if it is not well contained," said micribiologist Dr Gail Cassell, a senior lecturer at Harvard Medical School.

She cautioned that the potential speed of its spread will not be known until more is learned about how the Pennsylvania patient was infected, and how present the colistin-resistant superbug is in the United States and globally.

In the United States, antibiotic resistance has been blamed for at least 2 million illnesses and 23,000 deaths annually.

Last year, the mcr-1 gene was found in people and pigs in China, raising alarm.

The potential for the superbug to spread from animals to people is a major concern, Dr Cassell added.

For now, Dr Cassell said people can best protect themselves from it and from other bacteria resistant to antibiotics by thoroughly washing their hands, washing fruits and vegetables thoroughly and preparing foods appropriately.

Experts have warned since the 1990s that especially dangerous superbugs could be on the horizon, but few drug-makers have attempted to develop drugs against them.