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The UK's prime minister will use her first appearance at the exclusive gathering to say that Brexit was a response to people feeling dispossessed.
According to leaks in the British media, Mrs May will say that globalisation and free markets have delivered wealth and prosperity for millions but that many others had experienced its downsides, such as having their jobs outsourced, wages undercut and their communities rapidly changed.
Her speech will be aimed at drumming up trade and investment, as she plans to tell world leaders that Britain is set to "rediscover" its role as a "great, global trading nation" outside Europe.
Taoiseach, Enda Kenny and Finance Minister, Michael Noonan are also in Davos.
They arrived yesterday - Mr Kenny has already held a series of bi-lateral talks with business and financial leaders, including Inga Beale, Lloyd’s of London chief executive.
The pair will be promoting Ireland as a country to do business in as Brexit and Trump's presidency in the US loom.
They will attend a dinner event hosted by the IDA later today.
They may be struggling to rediscover past glories on the pitch - but Manchester United are back on top of football's money league for the first time in 12 years.
'United' pipped Real Madrid and Barcelona - but experts are predicting the pound's fall against the euro could see them fall behind the Spanish giants again next year.
It became the first club to achieve a turnover of more than £500m in 2015/16, while Real, who had topped the list for the last 11 years, slipped to third - just £100,000 behind their Catalan rivals.
The Old Trafford club got a boost from record-breaking kit and sponsorship deals with Adidas and Chevrolet and a return to the Champions League during the otherwise underwhelming reign of Dutch manager Louis van Gaal.
With euro zone growth and inflation improving and showing signs that its recovery is sticking, today's first ECB meeting of the new year is expected to be a quiet one.
Key rates are expected to remain unchanged and the central bank already unveiled its stimulus plans for 2017 at its December meeting. The bank's president Mario Draghi will take questions from journalists at his 13:30 press conference.
The ECB will continue to buy these assets until the end of 2017 - and beyond if it is deemed to be necessary. But it will pump €60bn in to the market every month - that's down from the current rate of €80bn until March of next year.