Robbie Henshaw is out of Connacht's Pro 12 clash with Scarlets.
The centre has failed to recover in time from a hip injury suffered in Ireland's defeat of Australia.
Rodney Ah You returns at loosehead, with Tom McCartney earning his first start at hooker.
The other changes to the pack sees Eoin McKeon replace Willie Faloon at openside, and Andrew Browne replacing Mick Kearney in the second row.
Kieran Marmion returns from Ireland duty to relace Ian Porter at scrum-half and he is partnered in the three-quarters by Jack Carty.
15. Mils Muliaina
14. Danie Poolman
13. Bundee Aki
12. Dave McSharry
11. Matt Healy
10. Jack Carty
9. Kieran Marmion
1. Denis Buckley
2. Tom McCartney
3. Rodney Ah You
4. Quinn Roux
5. Andrew Browne
6. John Muldoon (captain)
7. Eoin McKeon
8. George Naoupu