A pharmaceutical firm is to employ 175 people in Loughrea, Co Galway.
It comes as part of a €70 million investment by Chanelle Pharmaceuticals, which will be used to invest in Research and Development and to double capacity at the Loughrea plant.
45 jobs will be created during construction.
The firm wants to launch 75 new human and veterinary pharmaceutical products on worldwide markets.
Taoiseach Enda Kenny welcomed the announcement, saying: "It is most welcome that Chanelle is increasing its workforce to over 550 people in the West of Ireland and I congratulate Michael Burke on his achievements".
Michael Burke, Founder and Managing Director, Chanelle Group said; "In the past five years revenue has grown 100% and employment has increased by over 200 people. This growth has been driven by research and development of new products and the expansion into new markets. We invest over €8million annually in research and development and this investment will continue as we launch 75 new products over the next five years in both human and veterinary products.
Mr Burke added that Chanelle Group will be expanding into new markets including the United States, Central and South America.
The Chanelle Group currently employs 375 people in Ireland, the UK, Jordan and India.